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Again, it's- Andrew Huberman: Makes sense based on fetal development

This direct pathway provides immediate substrate availability but faces limitations through arginase enzymes in the liver and intestines, which can metabolize significant portions of ingested l-arginine before reaching target tissues

Certain drugs affect methylation and transsulfuration cycles, increasing tissue damage and reactive oxygen species

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According to research from Harvard Medical School, combining periodic injections with daily sublingual supplementation helps certain populations maintain stable B12 levels more effectively than either approach alone